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Anksiyete araştırmalarında kullanılan sıçan davranış modelleri
(Aykaç, Aslı.) |
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Bibliographical information (record 265411) |
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- This review focuses on the methods of study that investigated the
anxiolytic effects of new drugs with animal models. In a research
setting, researchers investigate inquiry and recognition behavior
changes of animals with anxiety in response to drug therapy. This
forms the basis of a research. Although, “anxious” behaviors
of rats do not exactly match the actual human behavior, they
are still used as a model of human behavior. Several different
stressor agents have been used including electric shocks, tilting
the cage, olfactory bulbectomy, elevation of the setup, changing
the lighting situation, under water trauma or exposure to predator
materials. In these studies, generally the reaction to the stress
is tested by observing the changes in the “anxious” behavior,
cognitive impairment, fear and decreased social interaction.
Frequently used models are; open field test, forced swimming
test, social isolation, conflict tests, repeated stress test, tail
suspension test, elevated maze tests, single prolonged test and
chronical mild stress predator scane test.
We explain various rat models and their properties and show
how they are used to create anxiety with different stressor agents.
Ease and repeatability of these models suggest that they are
effective for studying drugs for the prevention and treatment of
anxiety.
- Klinik öncesi çalışmalar kapsamında oluşturulan hayvan ve tekrarlanabilir oluşları, yeni geliştirilmekte olan ilaçların ya da mevcut benzer ilaçların anksiyeteyi önleme ve tedavi edici etkileri daha etkin olarak araştırılmaktadır
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Barcode |
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Library |
Section |
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EOL-782
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Item available
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NEU Grand LibraryOnline (WM170 .A55 2015)
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Online electronic |
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