a Record control number 000259659800008

a ISSN 0940-2993

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QV 600

b Item number .E34 2008

a Personal name Mehmetcik, Gueldal.

h Medium Electronic Document

a Title Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress

c Statement of responsibility, etc Gueldal Mehmetcik, Guel Oezdemirler, Necla Kocak-Toker, Ugur Cevikbas, Muejdat Uysal.

c Date of publication, distribution, etc 2008.

b Name of publisher, distributor, etc Elsevier,

a Place of publication, distribution, etc Jena :

a Summary, etc Artichoke is a plant with antioxidant properties. In this study, we investigated the effect of artichoke extract pretreatment on carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity. Rats were given artichoke leaf extract (1.5 g/kg/day) by gavage for 2 weeks and after then CCl(4) (1 ml/kg; i.p.) was applied. All rats were killed 24 11 after the CCl(4) injection. CCl(4) administration resulted in hepatic necrosis and significant increases in plasma transaminase activities as well as hepatic malondialdehyde (MDA) and diene conjugate (DC) levels in the liver of rats. Glutathione (GSH) and vitamin C levels decreased, but vitamin E levels increased in the liver Of CCl(4)-treated rats. Hepatic Superoxide dismutase (SOD) activities remained unchanged, but glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities decreased following CCl(4) treatment. In rats pretreated with artichoke extract, significant decreases in plasma transaminase activities and amelioration in histopathological changes in the liver were observed following CCl(4) treatment as compared to CCl(4)-treated rats. In addition, hepatic MDA and DC levels decreased, but GSH levels and GSH-Px activities increased without any change in other antioxidant parameters following CCl(4) treatment in artichoke-pretreated rats. The present findings indicate that in vivo architoke extract administration may be useful for the prevention of oxidative stress-induced hepatotoxicity. (C) 2008 Elsevier GmbH. All rights reserved.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Toxicology

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Artichoke

a Topical term or geographic name as entry element Carbontetrachloride

a Topical term or geographic name as entry element Oxidative stress.

g Relationship information SEP 2008, Vol 60 Issue 6, p475-480

t Title Experimental And Toxicologic Pathology

x International Standard Serial Number 09402993

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.etp.2008.04.014